TY - JOUR T1 - <em>Lactobacillus reuteri</em> is an effective option for the prevention of diarrhoea in preschool children but may not be cost-effective in all settings JF - Evidence Based Medicine JO - Evid Based Med SP - 212 LP - 212 DO - 10.1136/ebmed-2014-110039 VL - 19 IS - 6 AU - Yvan Vandenplas Y1 - 2014/12/01 UR - http://ebm.bmj.com/content/19/6/212.abstract N2 - Commentary on: Gutierrez-Castrellon P, Lopez-Velazquez G, Diaz-Garcia L, et al. Diarrhea in preschool children and Lactobacillus reuteri: a randomized controlled trial. Pediatrics 2014;133:e904–9.OpenUrlAbstract/FREE Full Text Diarrhoea remains a serious health burden for young children worldwide, with a high incidence of morbidity and mortality in the developing world. Oral rehydration solution dramatically improves outcomes, but does not influence the duration of diarrhoea. Selected probiotic strains have been shown to reduce the duration of acute gastroenteritis by around 24 h.1 Gutierrez-Castrellon and colleagues set out to evaluate whether probiotics administered in prevention could reduce the incidence of infectious gastroenteritis. Much attention has been paid to the study design by the authors. The probiotics and placebo arms were identical, except for the presence of the probiotic Lactobacillus reuteri, given daily over 12 weeks to … ER -