TY - JOUR T1 - Radical prostatectomy does not improve survival compared to observation for localised prostate cancer in a prospective randomised trial JF - Evidence Based Medicine JO - Evid Based Med SP - 139 LP - 140 DO - 10.1136/eb-2012-100994 VL - 18 IS - 4 AU - Joshua G Griffin AU - Jeffrey M Holzbeierlein Y1 - 2013/08/01 UR - http://ebm.bmj.com/content/18/4/139.abstract N2 - Commentary on: Wilt TJ, Brawer MK, Jones KM, et al. Prostate Cancer Intervention versus Observation Trial (PIVOT) Study Group. Radical prostatectomy versus observation for localized prostate cancer. N Engl J Med 2012; 367: 203– 13.OpenUrlCrossRefPubMedWeb of Science The beneficial role of prostate cancer screening and treatment has recently been called into question. The results of two recent trials have provided conflicting results with regard to the ability of prostate cancer screening to reduce prostate cancer-specific mortality.1 The Prostate Cancer Intervention versus Observation Trial (PIVOT) goes one step further by attempting to assess the efficacy of radical prostatectomy compared with observation, on overall and prostate cancer specific, survival in patients with localised prostate cancer. While there have been two trials conducted previously to address this issue, both took place prior to the prostate-specific antigen (PSA) era and they produced conflicting results.2 ,3 This … ER -