TY - JOUR T1 - High-dose vitamin D supplementation does not alter bone mass or muscle function over 1 year in postmenopausal women JF - Evidence Based Medicine JO - Evid Based Med SP - 30 LP - 30 DO - 10.1136/ebmed-2015-110328 VL - 21 IS - 1 AU - Nicholas C Harvey AU - Cyrus Cooper Y1 - 2016/02/01 UR - http://ebm.bmj.com/content/21/1/30.abstract N2 - Commentary on: Hansen KE, Johnson RE, Chambers KR, et al. Treatment of vitamin D deficiency in postmenopausal women: a randomised clinical trial. JAMA Intern Med 2015;175:1612–21.OpenUrlCrossRefPubMedAs recent systematic reviews have demonstrated, associations documented in observational studies between low vitamin D status and a wide range of disease outcomes have generally not been borne out by randomised control trials conducted thus far1; even for the traditional vitamin D-related outcomes of bone mineralisation and muscle function, such intervention studies have not provided a uniform message.2 Indeed there is continued controversy regarding what constitutes an optimal serum 25-hydroxyvitamin D concentration [(25OH)D].3Against this backdrop, Hanson et al aimed to … ER -