TY - JOUR T1 - Lower target oxygen saturation levels in preterm infants are associated with increased mortality and decreased rates of retinopathy of prematurity JF - Evidence Based Medicine JO - Evid Based Med SP - 20 LP - 20 DO - 10.1136/eb-2013-101463 VL - 19 IS - 1 AU - Daniele Trevisanuto AU - Veronica Mardegan Y1 - 2014/02/01 UR - http://ebm.bmj.com/content/19/1/20.abstract N2 - Commentary on: BOOST II UK Collaborative Group; BOOST II Australia Collaborative Group; BOOST II New Zealand Collaborative Group, et al. Oxygen saturation and outcomes in preterm infants. N Engl J Med 2013;368:2094–104.OpenUrlCrossRefPubMedWeb of Science The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimising oxygen toxicity and oxidative stress. Although many extremely preterm infants receive supplemental oxygen for prolonged periods, the optimal oxygen saturation has not yet been defined. The Benefits Of Oxygen Saturation Targeting (BOOST) II randomised controlled trial (RCT) aimed to evaluate the effects of targeting an oxygen saturation of 85–89%, as compared with a range of 91–95%, on disability-free survival at 2 years in infants born before 28 weeks’ gestation. During the study period, two major changes were made to the original study protocol; first, in the midst of the UK and Australian trials, … ER -