TY - JOUR T1 - Delaying initiation of ART for 5 weeks improves survival in patients with HIV infection with cyrptococcal meningitis JF - Evidence Based Medicine JO - Evid Based Med SP - 15 LP - 15 DO - 10.1136/ebmed-2014-110073 VL - 20 IS - 1 AU - A Tariro Makadzange AU - Nomvuyo Mothobi Y1 - 2015/02/01 UR - http://ebm.bmj.com/content/20/1/15.abstract N2 - Commentary on: Boulware DR, Meya DB, Muzoora C, et al. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med 2014;370:2487–98.OpenUrlCrossRefPubMedWeb of ScienceCryptococcal meningitis (CM) is a major cause of mortality for individuals with HIV infection in Africa. Early initiation of antiretroviral therapy (ART) has been shown to decrease mortality in a number of opportunistic infections such as tuberculosis (TB) and Pneumocystis jirovicii pneumonia, but may increase mortality in central nervous system-related opportunistic infections such as TB meningitis.1 The timing of ART however remains controversial for CM.2 ,3The study by Bouleware and colleagues is a randomised trial that assigned 177 HIV-infected ART-naïve patients from Uganda and South Africa who were recently diagnosed with CM (median of 7–8 days) to either receive ART within 48 h of randomisation (early … ER -