TY - JOUR T1 - The risk of arterial thrombosis increases with the use of combined oral contraceptives JF - Evidence Based Medicine JO - Evid Based Med SP - 38 LP - 38 DO - 10.1136/ebmed-2015-110303 VL - 21 IS - 1 AU - Øjvind Lidegaard Y1 - 2016/02/01 UR - http://ebm.bmj.com/content/21/1/38.abstract N2 - Commentary on: Roach RE, Helmerhorst FM, Lijfering WM, et al. Combined oral contraceptives: the risk of myocardial infarction and ischemic stroke. Cochrane Database Syst Rev 2015;8:CD011054.While the risk of venous thrombosis with use of combined oral contraceptives (COC) is now convincingly quantified to be threefold to sixfold increased, depending mainly on the type of progestogen, there are few and less consistent studies on the risk of arterial endpoints. Therefore, a meta-analysis on available evidence might be relevant.This Cochrane review includes data from 24 studies assessing the risk of thrombotic stroke and/or myocardial infarction in women of reproductive age using COC as compared with non-users. Criteria for including and excluding studies were specified, as was information on categorising the studies’ … ER -