TY - JOUR T1 - Observational studies are compatible with an association between saturated and trans fats and cardiovascular disease JF - Evidence Based Medicine JO - Evid Based Med SP - 37 LP - 37 DO - 10.1136/ebmed-2015-110298 VL - 21 IS - 1 AU - Lee Hooper AU - Jim Mann Y1 - 2016/02/01 UR - http://ebm.bmj.com/content/21/1/37.abstract N2 - Commentary on: de Souza RJ, Mente A, Maroleanu A, et al. Intake of saturated and trans unsaturated fatty acids and risk of all-cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ 2015;351:h3978.What is the relationship between saturated or trans fats in our food and cardiovascular risk? To find out we must examine the totality of interventional and observational evidence and all appropriate outcomes. The WHO Nutrition Guidance Advisory Group (WHO NUGAG) recently commissioned systematic reviews of randomised controlled trials (RCTs) which examined effects of modifying saturated or trans fat intakes on mortality or cardiovascular health1 ,2 and controlled trials on lipid outcomes (updates of these published reviews are due to be published),3 ,4 as well as this systematic review of observational data (reported by de Souza and colleagues).This systematic review included observational … ER -