TY - JOUR T1 - Potential confounding still clouds the possible association of maternal caffeine intake and low birth weight JF - Evidence Based Medicine JO - Evid Based Med SP - 37 LP - 37 DO - 10.1136/ebmed-2014-110116 VL - 20 IS - 1 AU - Michael B Bracken Y1 - 2015/02/01 UR - http://ebm.bmj.com/content/20/1/37.abstract N2 - Commentary on: Chen LW, Wu Y, Neelakantan N, et al. Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. BMC Med 2014;12:174.OpenUrlCrossRefPubMedThe possible association of maternal caffeine intake to a variety of pregnancy outcomes (eg, low birth weight (LBW), fetal growth restriction, preterm delivery) is important because of widespread exposure to caffeine. If caffeine were causally related to these outcomes, it would be amenable to risk reduction through caffeine reduction or abstention.This was a systematic review and meta-analysis of prospective observational studies of maternal caffeine exposure and LBW. The Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines were followed. Acceptable standards for literature searching, study selection and data extraction were adhered … ER -