TY - JOUR T1 - Aerobic exercise training reduces bronchial hyper-responsiveness and serum pro-inflammatory cytokines in patients with asthma JF - Evidence Based Medicine JO - Evid Based Med SP - 70 LP - 70 DO - 10.1136/ebmed-2015-110260 VL - 21 IS - 2 AU - Stefano R del Giacco AU - Vanessa Garcia-Larsen Y1 - 2016/04/01 UR - http://ebm.bmj.com/content/21/2/70.abstract N2 - Commentary on: França-Pinto A, Mendes FAR, de Carvalho-Pinto RM, et al. Aerobic training decreases bronchial hyper-responsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial. Thorax 2015;70:732–9.OpenUrlAbstract/FREE Full TextExercise is a well-known trigger for asthma symptoms. In patients with asthma, strenuous physical activity increases the risk of an asthma attack, with a ‘U’-shaped curve showing that moderate exercise training carries a lower risk of asthma compared to high-intensity exercise training. Lack of physical activity appears to be independently associated with increased bronchial hyper-responsiveness (BHR).1 These observations are confirmed by a growing number of murine studies, but reviews examining the epidemiological evidence for such associations in humans show that the overall evidence on exercise and asthma is, at best, very … ER -