TY - JOUR T1 - Early initiation of antiretroviral therapy prevents HIV transmission to seronegative sexual partners JF - Evidence Based Medicine JO - Evid Based Med SP - 29 LP - 29 DO - 10.1136/ebmed-2016-110576 VL - 22 IS - 1 AU - George W Rutherford AU - Andrew Anglemyer Y1 - 2017/03/01 UR - http://ebm.bmj.com/content/22/1/29.abstract N2 - Commentary on: Cohen MS, Chen YQ, McCauley M, et al. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med 2016;375:830–9OpenUrlCrossRefPubMed.In 2011, interim results from the HIV Prevention Trials Network (HPTN) 052 trial confirmed that early antiretroviral therapy (ART) markedly reduces HIV transmission in serodiscordant couples.1 This, along with evidence that therapeutic benefits accrue from starting ART earlier,1–3 led the WHO to recommend that all patients with HIV infection start ART as soon as possible after diagnosis.4 Cohen et al have now published a final analysis from their original HPTN 052 report.The HPTN 052 trial randomised ART-naïve participants to initiate ART early, between 350 and 550 CD4 cells/µL, or to delay initiation until 250 cells/µL. Uninfected primary … ER -