TY - JOUR T1 - Stroke rates vary substantially across cohorts of patients with atrial fibrillation JF - Evidence Based Medicine JO - Evid Based Med DO - 10.1136/ebmed-2017-110711 SP - ebmed-2017-110711 AU - Luciano A Sposato AU - Gustavo Saposnik Y1 - 2017/04/12 UR - http://ebm.bmj.com/content/early/2017/04/12/ebmed-2017-110711.abstract N2 - Commentary on: Quinn GR, Severdija ON, Chang Y, et al. Wide variation in reported rates of stroke across cohorts of patients with atrial fibrillation. Circulation 2017;135:208–19.OpenUrlAbstract/FREE Full TextOral anticoagulants (OACs) substantially reduce stroke risk in patients with atrial fibrillation (AF); however, they remain globally underused.1 One of the main reasons is the difficulty in stratifying AF-related ischaemic stroke risk at the individual patient level.1 ,2 Among scores stratifying AF-related stroke risk, CHA2-DS2-Vasc prevails in most recent international AF guidelines.3 ,4 Still, it remains unknown whether AF-related stroke risk is stable across regions, international cohorts or within specific CHA2-DS2-Vasc score strata.This systematic review included only studies reporting ischaemic stroke rates for patients with AF not on OACs, and assessed … ER -