TY - JOUR T1 - Early invasive strategy should be performed within 72 hours in high-risk patients with non-ST-elevation myocardial infarction JF - Evidence Based Medicine JO - Evid Based Med SP - 227 LP - 227 DO - 10.1136/ebmed-2017-110848 VL - 22 IS - 6 AU - Carlos Collet AU - Patrick W Serruys Y1 - 2017/12/01 UR - http://ebm.bmj.com/content/22/6/227.abstract N2 - Commentary on: Jobs A, Mehta SR, Montalescot G, et al. Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials. Lancet 2017;390:737–46.The mainstay of treatment for patients presenting with non-ST-elevation acute coronary syndrome (NSTE-ACS) is medical therapy, early coronary angiography and revascularisation. A routine invasive strategy has been shown to reduce all-cause death and myocardial infarction  compared with a conservative approach at 5 years.1 Therefore, an early invasive strategy with intent to perform revascularisation is advocated in the 2014 American and European guidelines with a class I recommendation.2 3 While immediate angiography is recommended for extremely high-risk patients (eg, haemodynamic or electrical instability, persistent angina, heart failure or worsening mitral regurgitation), the optimal timing for an invasive approach in patients … ER -