TY - JOUR T1 - Low carbohydrate diets should NOT be recommended for patients with familiar hypercholesterolaemia JF - BMJ Evidence-Based Medicine JO - BMJ EBM DO - 10.1136/bmjebm-2020-111563 SP - bmjebm-2020-111563 AU - Roman Pawlak Y1 - 2020/10/01 UR - http://ebm.bmj.com/content/early/2020/09/30/bmjebm-2020-111563.abstract N2 - Diamond et al1 have questioned the efficacy of low-saturated fat, low-cholesterol diet to reduce LDL cholesterol in individuals with familiar hypercholesterolaemia (FH) and suggested that these patients be introduced to low carbohydrate diets (LCD). There are several problems with their suggestions, the main one is addressed in this letter.Evidence from animal and human studies showed that LCD, which usually are also high in protein (LCHP) and/or fat, exacerbate atherosclerosis independently of ‘significant alterations in traditional atherogenic serum lipids, serum inflammatory markers and histological indicators of inflammatory infiltration’2 and they … ER -