RT Journal Article SR Electronic T1 Considerations on the strengths and limitations of using disease-related mortality as an outcome in clinical research JF BMJ Evidence-Based Medicine JO BMJ EBM FD BMJ Publishing Group Ltd SP 127 OP 130 DO 10.1136/bmjebm-2018-111154 VO 26 IS 3 A1 Jakobsen, Janus Christian A1 Wetterslev, Jørn A1 Gluud, Christian YR 2021 UL http://ebm.bmj.com/content/26/3/127.abstract AB Disease-related mortality (eg, cardiovascular mortality or breast-cancer mortality) is often used as an outcome in randomised clinical trials and systematic reviews. The rationale why disease-related mortality might be used in addition to, or instead of, all-cause mortality seems to be that disease-related mortality may more readily detect the experimental intervention effects. Disease-related mortality is theoretically what most interventions aim at influencing; disease-related intervention effects are not ‘diluted’ by events unrelated to the disease that may be occurring in both the experimental group and the control group (eg, traffic accidents). Intervention–effect estimates are indeed theoretically diluted and affected if events unrelated to the disease or the trial interventions are occurring. Although sounding attractive, we will in the present paper consider the several methodological limitations of using disease-related mortality instead of all-cause mortality as an outcome. When mortality is a relevant outcome, we recommend using all-cause mortality as a primary outcome and disease-specific mortality as a secondary or exploratory outcome depending on power.