TY - JOUR T1 - Upholding trust in therapeutic trials and evidence-based medicine: need for full disclosure of data, crowdsourcing data analysis and independent review? JF - BMJ Evidence-Based Medicine JO - BMJ EBM SP - 149 LP - 152 DO - 10.1136/bmjebm-2019-111242 VL - 26 IS - 4 AU - Pierre Vladimir Ennezat AU - Raphaëlle Ashley Guerbaai AU - Thierry H Le Jemtel Y1 - 2021/08/01 UR - http://ebm.bmj.com/content/26/4/149.abstract N2 - An active 74-year-old woman with hypertension and a family history of hypercholesterolaemia was referred for evaluation of chest pain and underwent coronary angiography. Low-density lipoprotein (LDL) cholesterol was 270 mg/dL. Coronary and carotid arteries were patent, and the echocardiogram was normal. The patient could not tolerate statins due to incapacitating muscle weakness and pain. Age combined with a history of familial hypercholesterolaemia are high cardiovascular risk factors, and the 2019 European Society of Cardiology guidelines recommend LDL cholesterol reduction by at least 50% from baseline and targeting LDL cholesterol <55 mg/dL (class IIa, level of evidence C).1 She declined the recently marketed treatment with proprotein convertase subtilisin/kexin type-9 serine protease (PCSK9) inhibitor due to the lack of long-term outcome data.In early 2019, the editors-in-chief of leading cardiovascular journals wrote a joint editorial (published in 15 journals) that held media responsible for the distrust in vaccination and statin therapy.2 In 1996, the editor-in-chief of the American Journal of Cardiology wrote that statins are to atherosclerosis what penicillin is to infectious disease3; Fausto Pinto, immediate ESC past-president, stated ‘After antibiotics, statins may have contributed more to prolonging life expectancy than any other type of medications’. We discuss in the following sections, the overestimation of the effect of statins, as well as the small size effect present in most trials and methodological bias.The results of positive statin trials are commonly viewed as impressive with a relative risk reduction of events of 20%–40%, when the absolute risk reduction is a modest 1%–5% (see online supplementary table 1). Danish investigators did evaluate the beneficial effects of statins on outcome as a postponement of death by a median of 10.2 and 17.4 days over the duration of relevant primary and secondary prevention trials, respectively.4 Similarly, ezetimibe, which has no effect on … ER -