TY - JOUR T1 - Should clinical practice change to bedtime administration of antihypertensive? JF - BMJ Evidence-Based Medicine JO - BMJ EBM SP - e6 LP - e6 DO - 10.1136/bmjebm-2020-111435 VL - 26 IS - 6 AU - Jian-Yu E Y1 - 2021/12/01 UR - http://ebm.bmj.com/content/26/6/e6.abstract N2 - Chronotherapy provides a new option to optimise hypertension and reduce cardiovascular risks based on the circadian profile of blood pressure.1 A recent Hygia trial reported taking bedtime antihypertensives reduced cardiovascular disease (CVD) risk by 45% compared with ingestion of medications on awakening.2 However, two key points related to the design and reporting of this trial should be considered in developing guidelines for optimal timing of antihypertensive use.The Hygia trial reported that there was no treatment-time difference in prevalence of all adverse events and sleep time hypotension. Unexpectedly, they … ER -