TY - JOUR T1 - Replacing PICO in non-interventional studies JF - BMJ Evidence-Based Medicine JO - BMJ EBM DO - 10.1136/bmjebm-2021-111889 SP - bmjebm-2021-111889 AU - Yishai Mintzker AU - Dalit Blum AU - Limor Adler Y1 - 2022/01/10 UR - http://ebm.bmj.com/content/early/2022/01/10/bmjebm-2021-111889.abstract N2 - Dr Luijendijk1 has identified an elephant in the evidence-based medicine (EBM) classroom: patient, intervention, comparison, outcome (PICO acronym) for the formulation of clinical questions, teaching EBM and searching the literature is extremely useful for interventional studies but confusing for other types of studies. Instead of forcing words into the acronym, we suggest adding two acronyms.The acronym PECO (E for exposure) can replace PICO in observational studies. This acronym is already used for environmental exposures2 but can be used for any exposure, including … ER -