PT - JOURNAL ARTICLE AU - Jessica Malmqvist AU - Volkert Dirk Siersma AU - Mie Sara Hestbech AU - Christine Winther Bang AU - Dagný Rós Nicolaisdóttir AU - John Brodersen TI - Short and long-term psychosocial consequences of participating in a colorectal cancer screening programme: a matched longitudinal study AID - 10.1136/bmjebm-2020-111576 DP - 2022 Apr 01 TA - BMJ Evidence-Based Medicine PG - 87--96 VI - 27 IP - 2 4099 - http://ebm.bmj.com/content/27/2/87.short 4100 - http://ebm.bmj.com/content/27/2/87.full SO - BMJ EBM2022 Apr 01; 27 AB - Objectives To investigate the psychosocial consequences of receiving a false-positive (no abnormalities) result or being diagnosed with polyps compared with receiving a negative result in a colorectal cancer (CRC) screening programme.Design and setting This was a longitudinal study nested in the roll-out of the Danish CRC screening programme that targets all individuals aged 50–74 years.Participants In the inclusion period (April–September 2017), all positive screenees (n=1854) were consecutively enrolled and matched 2:1:1 on sex, age (±2 years), municipality and screening date with negative screenees (n=933) and individuals not yet invited to screening (n=933).Questionnaires were sent by mail to all eligible participants in Region Zealand, Denmark, after the screening result, 2 months and 12 months after the final result.Positive screenees who did not receive the follow-up procedure were excluded.Main outcome measures The primary outcomes were psychosocial consequences. Outcomes were measured with the CRC screening-specific questionnaire Consequences of screening in CRC with 11 outcomes after the screening result and with 21 outcomes at the two later assessments.Results After receiving the screening result, individuals with no abnormalities, low-risk and medium-risk and high-risk polyps scored significantly worse on 8 of 11 outcomes compared with the negative screenee group. At the 12-month follow-up, the differences were still significant in 8 of 21 outcomes (no abnormalities), 4 of 21 outcomes (low-risk polyps) and 10 of 21 outcomes (medium-risk and high-risk polyps). The negative screenee group and the group not yet invited to screening differed psychosocially on 5 of 11 outcomes after the screening result, but on none of the 21 outcomes at the 2 months and 12 months follow-up.Conclusions The study showed that there are both short-term and long-term psychosocial consequences associated with receiving a no abnormalities result or being diagnosed with polyps. The consequences were worst for individuals diagnosed with medium-risk and high-risk polyps.Data are available on reasonable request. Data and questionnaires are available on reasonable request from the corresponding author.