Orlistat (Orl) or sibutramine (Sib) v placebo for weight loss at 1 year*
| Outcomes | Number of trials | Weighted event rates | RBI (95% CI) | NNT (CI) | ||
|---|---|---|---|---|---|---|
| Orl | Sib | Placebo | ||||
| *Abbreviations defined in glossary; weighted event rates, RBI, NNT, and CI calculated from data in article using a random effects model. | ||||||
| 5% weight loss | 11 | 52% | – | 31% | 75% (53 to 100) | 5 (5 to 6) |
| 3 | – | 49% | 15% | 256% (132 to 446) | 3 (3 to 4) | |
| 10% weight loss | 10 | 25% | – | 13% | 93% (66 to 125) | 9 (7 to 13) |
| 3 | – | 20% | 5% | 345% (168 to 639) | 7 (4 to 25) | |