Intensive lifestyle intervention (ILS) or metformin plus standard lifestyle v placebo plus standard lifestyle for prevention of metabolic syndrome*

Outcome at mean 3.2 yearsComparisonsCumulative incidenceRHR (95% CI)NNT (CI)†
*RHR  =  relative hazard reduction. Other abbreviations defined in glossary. †NNTs provided by author.
Incidence of metabolic syndromeILS v placebo38% v 61%41% (28 to 52)4 (3 to 7)
Metformin v placebo50% v 61%17% (0 to 31)9 (5 to 41)