Short term antidepressant treatment for bipolar depression*

ComparisonNumber of trials (n)Outcomes at 4–10 wksEvent ratesRBI (95% CI)NNT (CI)
*NS  =  not significant. RBR  =  relative benefit reduction. Other abbreviations defined in glossary. All statistics based on a fixed effects model. RBI, RRR, RBR, and RRI calculated from data in article. †Data provided by author.
Antidepressants v placebo4 (662)Clinical response58% v 34%86% (49 to 130)5 (4 to 7)
2 (573)Clinical remission43% v 31%41% (11 to 80)9 (5 to 33)
RRR (CI)
5 (779)Induction of mania3.8% v 4.7%0 (−113 to 53)NS
{5 (779)}†Study withdrawal32% v 49%29% (12 to 42){6 (4 to 10)}†
RBR (CI)
Tricyclics v other antidepressants5 (296)Clinical response47% v 56%16% (−6 to 33)NS
RRI (CI)NNH (CI)
6 (370)Induction of mania10% v 3.2%192% (28 to 571)15 (9 to 59)
{6 (370)}†Study withdrawal37% v 30%23% (−8 to 64)NS†