Comparison | Number of trials (n) | Outcomes at 4–10 wks | Event rates | RBI (95% CI) | NNT (CI) |
---|---|---|---|---|---|
*NS = not significant. RBR = relative benefit reduction. Other abbreviations defined in glossary. All statistics based on a fixed effects model. RBI, RRR, RBR, and RRI calculated from data in article. †Data provided by author. | |||||
Antidepressants v placebo | 4 (662) | Clinical response | 58% v 34% | 86% (49 to 130) | 5 (4 to 7) |
2 (573) | Clinical remission | 43% v 31% | 41% (11 to 80) | 9 (5 to 33) | |
RRR (CI) | |||||
5 (779) | Induction of mania | 3.8% v 4.7% | 0 (−113 to 53) | NS | |
{5 (779)}† | Study withdrawal | 32% v 49% | 29% (12 to 42) | {6 (4 to 10)}† | |
RBR (CI) | |||||
Tricyclics v other antidepressants | 5 (296) | Clinical response | 47% v 56% | 16% (−6 to 33) | NS |
RRI (CI) | NNH (CI) | ||||
6 (370) | Induction of mania | 10% v 3.2% | 192% (28 to 571) | 15 (9 to 59) | |
{6 (370)}† | Study withdrawal | 37% v 30% | 23% (−8 to 64) | NS† |