Weighted pooled sensitivity (sens) and specificity (spec) of tests for diagnosing celiac disease*
| Test (number of studies) | Adults | Children | Mixed | |||
|---|---|---|---|---|---|---|
| Sens (95% CI) | Spec (CI) | Sens (CI) | Spec (CI) | Sens (CI) | Spec (CI) | |
| *AGA = antigliadin antibody; EMA = endomyseal antibody; ME = monkey oesophagus; HU = human umbilical cord; tTG = transglutaminase antibody; GP = guinea pig; HR = human recombinant; H = pooled estimate not calculated because of study heterogeneity; na = not available. CI defined in glossary. | ||||||
| IgA-AGA (35) | 75–90% | 80–90% | 80–95% | 80–95% | H | H |
| IgG-AGA (34) | H | H | H | H | H | H |
| IgA-EMA-ME (35) | 97% (96 to 99) | 100% (99 to 100) | 96% (95 to 97) | 97% (96 to 98) | 80–90% | 100% (98 to 100) |
| IgA-EMA-HU (13) | 90% (86 to 93) | 100% (99 to 100) | 97% (94 to 99) | H | 93% (88 to 95) | 100% (98 to 100) |
| IgA-tTG-GP (9) | 86% (81 to 90) | 95% (93 to 97) | 93% (89 to 96) | 96 (93 to 98) | 85–95% | 95% (93 to 97) |
| IgG-tTG-GP (3) | na | na | na | na | 45% (36 to 54) | 99% (94 to 100) |
| IgA-tTg-HR (10) | 98% (90 to 100) | 98% (96 to 99) | 96% (90 to 98) | 99% (95 to 100) | 90% (86 to 93) | 95% (92 to 98) |