Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) v calcium antagonists (CAs) or placebo for diabetes with and without nephropathy*

OutcomesComparisonsNumber of trials (n)Relative risk (95% CI)
*CI defined in glossary.
†Not significant.
Onset of microalbuminuria in diabetes without nephropathyACE inhibitors v CAs4 (1210)0.58 (0.40 to 0.84)
ACE inhibitors v placebo6 (3840)0.60 (0.43 to 0.84)
All cause mortality in diabetic nephropathyACE inhibitors v placebo20 (2838)0.79 (0.63 to 0.99)
ARBs v placebo4 (3329)0.99 (0.85 to 1.17)†