Stepped care with chlorthalidone v placebo for older patients with isolated systolic hypertension*

Outcomes at median 14.3 yearsStepped carePlaceboRRR (CI)NNT (CI)
*Abbreviations defined in glossary; RRR, NNT, and CI calculated from hazards ratios in article.
All cause mortality41%43%5.9% (−0.7 to 12)Not significant
Cardiovascular mortality19%22%13% (2.5 to 23)36 (21 to 186)