Water v saline or other solutions for cleansing wounds*
Outcomes at 1–6 weeksNumber of trials (n)ComparisonsWeighted event ratesRRR (95% CI)NNT (CI)
Infection3† (1338)Tap water v saline4.4% v 7%37% (1 to 60)39 (24 to 1432)
1‡ (49)Tap water v saline0% v 12%84% (−196 to 99)Not significant
1 (55)Distilled water v saline17% v 35%51% (−26 to 81)Not significant
1 (51)Cool boiled water v saline29% v 35%17% (−87 to 63)Not significant
Healing1‡ (49)Tap water v saline35% v 62%43% (−7 to 70)Not significant
RRI (CI)NNH
Infection1 (66)Distilled v cool boiled water29% v 17%69% (−32 to 322)Not significant
  • *Abbreviations defined in glossary. RRR, RRI, NNT, NNH, and CI calculated from data in article using a fixed-effects model.

  • †2 RCTs and 1 quasi-RCT that evaluated acute wounds.

  • ‡RCT evaluated chronic wounds.

  • *Abbreviations defined in glossary. RRR, RRI, NNT, NNH, and CI calculated from data in article using a fixed-effects model.

  • †2 RCTs and 1 quasi-RCT that evaluated acute wounds.

  • ‡RCT evaluated chronic wounds.