Cardiovascular (CV) safety of 400 and 800 mg/day of celecoxib for colorectal adenomas at 2.8–3.1 years*

OutcomeComparisonsEvent ratesRRI (95% CI)NNH (CI)
*MI  =  myocardial infarction. Other abbreviations defined in glossary; RRI, NNH, and CI calculated from hazard ratios in article. †Primary composite endpoint.
CV death, non-fatal MI, stroke, or heart failure†Celecoxib 800 v placebo3.4% v 1.0%236% (40 to 654)43 (16 to 252)
Celecoxib 400 v placebo2.3% v 1.0%129% (−10 to 438)Not significant