Antidepressants v placebo for unexplained symptoms or syndromes*

Number of RCTs for each antidepressant type
Symptom groupsTCASSRIAnti-SOther Mean quality scorePooled OR (95% CI)†
*Anti-S=antiserotonin; GI=gastrointestinal; OR=odds ratio; RCTs=randomised controlled trials; SSRI=selective serotonin reuptake inhibitor; TCA=tricyclic antidepressant. Median follow up was 9 weeks.
†Odds ratios show a benefit for the antidepressant group.
Chronic headache218234.63.4 (2.7 to 4.4)
Fibromyalgia12435.85.1 (3.1 to 8.5)
Functional GI disorders11214.14.4 (2.5 to 7.7)
Idiopathic pain8224.22.0 (1.4 to 2.8)
Chronic fatigue24.0
All56172834.83.4 (2.6 to 4.3)