Amoxicillin v placebo for children ≤2 years of age with acute otitis media‡

OutcomesAmoxicillinPlaceboRRR (95% CI)NNT (CI)
Persistent symptoms at 4 days59%72%18% (2 to 33)8 (4 to 72)
Adjusted RRR (CI)Adjusted NNT (CI)
14% (0.8 to 24)10 (6 to 169)
‡Adjustment was made for unequal baseline distribution of recurrence, day care attendance, and smoking. Abbreviations defined in glossary; RRR, NNT, and CI calculated from data in article.
Clinical failure at 11 days64%70%8% (−10 to 24)Not significant