Treatment response for lithium augmentation v placebo for refractory depression (treatment up to 42d)†

Weighted event rates‡RBI (95% CI)NNT (CI)
†Abbreviations defined in glossary. Treatment duration was 4 to 6 weeks.‡Event rates calculated from data in article and data supplied by author.
StudiesLithiumPlacebo 3 studies with sufficient dose and duration of lithium50%23%114% (23 to 270)4 (3 to 11)
All 9 studies46%17%125% (45 to 251)4 (3 to 6)