Different dosing frequencies of 10 day penicillin or amoxicillin for acute group A β-haemolytic streptococcal tonsillopharyngitis†

ComparisonsNumber of RCTsWeighted cure ratesRBR (95% CI)NNH (CI)
†RBR = relative benefit reduction; RCTs = randomised controlled trials. Other abbreviations defined in glossary; RBR, NNH, and CI calculated from data in article.
‡Heterogeneity is statistically significant.
§Study involving amoxicillin was excluded.
Twice/day v 3 or 4 times/day484% v 85%2% (−5 to 8)Not significant
Once/day v 3 or 4 times/day3‡85% v 92%8% (−7 to 20)Not significant
Once/day v 3 or 4 times/day (excluding the amoxicillin study)79% v 91% 14% (4 to 23)9 (5 to 31)