Tiotropium v ipratropium at 13 weeks in chronic obstructive pulmonary disease (lung function improvement, in litres, compared with baseline at start of study)‡
| Outcomes | Tiotropium | Ipratropium | Mean difference (95% CI) |
|---|---|---|---|
| ‡FVC=forced vital capacity. | |||
| FEV1 trough | 0.16 | 0.03 | 0.13 (0.08 to 0.18) |
| FEV1 peak (at 50 d) | 0.38 | 0.30 | 0.08 (0.02 to 0.15) |
| FEV1 mean (over 6 h) | 0.26 | 0.18 | 0.08 (0.03 to 0.13) |
| FVC trough | 0.39 | 0.18 | 0.21 (0.10 to 0.32) |
| FVC mean (at 50 d) | 0.62 | 0.45 | 0.17 (0.50 to 0.29) |