Coumadin or coumadin plus aspirin (combination group) v aspirin alone in acute myocardial infarction or unstable angina at median follow up of 12 months†

OutcomesComparisonsEvent ratesRRR (95% CI)NNT (CI)
Composite end pointCoumadin v aspirin5% v 9%43% (1 to 68)26 (13 to 2740)
Combination v aspirin5% v 9%48% (7 to 71)23 (12 to 184)
†Composite end point = all cause mortality, myocardial infarction, or stroke. Abbreviations defined in glossary; RRI, RRR, NNT, NNH, and CI calculated from data in article.
Major bleedingCoumadin v aspirin1% v 1%3% (−76 to 345)Not significant
Combination v aspirin2% v 1%136% (−32 to 733)Not significant
Minor bleedingCoumadin v aspirin8% v 5%68% (−7 to 205)Not significant
Combination v aspirin15% v 5%216% (86 to 442)10 (7 to 17)