Hypericum extract (HE) v placebo at 6 weeks and HE v imipramine (Imi) at 8 weeks for moderate depression§

OutcomesComparisonEvent ratesRBI (95% CI)NNT (CI)
≥50% improvement in HDRS scoreHE v placebo67% v 48%40% (3.5 to 101)6 (3 to 50)
HE v Imi76% v 67%14% (−4.3 to 37)Not significant
§HDRS = Hamilton Depression Rating Scale. Other abbreviations defined in glossary; RBI, RRR, NNT, and CI calculated from data provided by the author.
Adverse effectsHE v Imi22% v 46%53% (30 to 69)4 (3 to 9)