Hypericum extract (HE) v placebo at 6 weeks and HE v imipramine (Imi) at 8 weeks for moderate depression§
| Outcomes | Comparison | Event rates | RBI (95% CI) | NNT (CI) |
|---|---|---|---|---|
| ≥50% improvement in HDRS score | HE v placebo | 67% v 48% | 40% (3.5 to 101) | 6 (3 to 50) |
| HE v Imi | 76% v 67% | 14% (−4.3 to 37) | Not significant |
| RRR (CI) | ||||
|---|---|---|---|---|
| §HDRS = Hamilton Depression Rating Scale. Other abbreviations defined in glossary; RBI, RRR, NNT, and CI calculated from data provided by the author. | ||||
| Adverse effects | HE v Imi | 22% v 46% | 53% (30 to 69) | 4 (3 to 9) |