Antidepressants v placebo for bulimia nervosa at 6 to 16 weeks*

OutcomesAntidepressant typeWeighted event ratesRBI (95% CI)NNT (CI)
*MAOIs = monoamine oxidase inhibitors; SSRIs = selective serotonin reuptake inhibitors; TCAs = tricyclic antidepressants. Other abbreviations defined in glossary; RBI, RRR, RRI, NNT, NNH, and CI calculated from data in article.
RemissionAll types20% v 7.9%105% (32 to 219)9 (6 to 16)
TCAs14% v 9.1%136% (–4 to 476)Not significant
MAOIs25% v 6.3%229% (–22 to 1289)Not significant
Other antidepressants15% v 0%664% (–1 to 5773)7 (4 to 27)
Clinical improvementAll types64% v 33% 84% (38 to 145)4 (3 to 5)
TCAs77% v 17%294% (59 to 872)2 (2 to 3)
SSRIs58% v 38% 51% (26 to 81)5 (4 to 9)
Other antidepressants44% v 8.2%321% (74 to 919)3 (3 to 5)
RRR (CI)NNT
Drop outsSSRIs34% v 40% 18% (1 to 32)Not significant
Other antidepressants30% v 32% 6% (–83 to 52)Not significant
RRI (CI)NNH
All types34% v 31% 3% (–20 to 32)Not significant
TCAs26% v 11% 93% (15 to 225)Not significant
MAOIs34% v 29% 20% (–33 to 113)Not significant