Risks associated with ever use of HRT from Nelson et al and from the Women’s Health Initiative [WHI])*
| Outcomes | Relative risk (95% CI) from Nelson et al | Hazard ratio (CI) from WHI |
|---|---|---|
| *Abbreviations defined in glossary; meta-analyses based on a random effects model. | ||
| †Statistically significant. | ||
| ‡Adjusted CIs. | ||
| Hip fractures | 0.76 (0.56 to 1.01) | 0.66 (0.33 to 1.33)‡ |
| Vertebral fractures | 0.60 (0.36 to 0.99)† | 0.66 (0.32 to 1.34)‡ |
| Colon cancer | 0.80 (0.74 to 0.86)† | 0.63 (0.32 to 1.24)‡ |
| Coronary heart disease events | 0.91 (0.67 to 1.33) | 1.29 (1.02 to 1.63)† |
| Stroke | 1.12 (1.01 to 1.23)† | 1.41 (0.86 to 2.31)‡ |
| Thromboembolic events (current use) | 2.14 (1.64 to 2.81)† | 2.11 (1.26 to 3.55)†‡ |
| Breast cancer (≥5 y HRT) | 1.23 to 1.35 | 1.26 (1.00 to 1.59)† |