Medical therapies for chronic anal fissure (outcome  =  healing of fissure)*

ComparisonWeighted event ratesRBI (95% CI)NNT (CI)
*GTN  =  glyceryl trinitrate; RBR  =  relative benefit reduction. Other abbreviations defined in glossary. Weighted event rates, RBI, RBR, NNT, NNH, and CI calculated from data in article using a random effects model.
GTN v placebo55% v 33%78% (7 to 198)5 (3 to 51)
GTN v placebo (excluding 2 trials with low placebo rates)54% v 40%35% (−15 to 115)Not significant
Medical therapy (GTN or botox) v surgery50% v 86%42% (21 to 58)3 (3 to 5)