Antihypertensive regimens with angiotensin-converting enzyme (ACE) inhibitors (treatment) v regimens without ACE inhibitors (control)*

Weighted event rates
Outcomes at 2 to 4 yearsTreatmentControlRRR (95% CI)NNT (CI)
ESRD10.5%11.5%34% (14 to 50)102 (36 to 114)
Doubling of serum creatinine or ESRD15.7%20.3%34% (18 to 47)22 (11 to 257)
ESRD or death11.1%12.7%23% (–7 to 45)Not significant
*ESRD = end stage renal disease. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data provided by author using a random effects model.
†A fixed effects model was used.
Death†2.4%1.2%63% (−219 to 16)Not significant