Antihypertensive regimens with angiotensin-converting enzyme (ACE) inhibitors (treatment) v regimens without ACE inhibitors (control)*
| Weighted event rates | ||||
|---|---|---|---|---|
| Outcomes at 2 to 4 years | Treatment | Control | RRR (95% CI) | NNT (CI) |
| ESRD | 10.5% | 11.5% | 34% (14 to 50) | 102 (36 to 114) |
| Doubling of serum creatinine or ESRD | 15.7% | 20.3% | 34% (18 to 47) | 22 (11 to 257) |
| ESRD or death | 11.1% | 12.7% | 23% (–7 to 45) | Not significant |
| RRI (CI) | NNH | |||
|---|---|---|---|---|
| *ESRD = end stage renal disease. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data provided by author using a random effects model. | ||||
| †A fixed effects model was used. | ||||
| Death† | 2.4% | 1.2% | 63% (−219 to 16) | Not significant |