Hormone replacement therapy (HRT) v placebo in community dwelling postmenopausal women at 5.6 years†
| Outcomes | Trial | HRT | Placebo | RRI (95% CI) | NNH (CI) |
|---|---|---|---|---|---|
| †WHI = Women’s Health Initiative; WHIMS = Women’s Health Initiative Memory Study; 3MSE = Modified Mini-Mental State Examination. Other abbreviations defined in glossary; RRI, NNH, and CI calculated from data in article. | |||||
| ‡Statistically significant difference favours placebo. | |||||
| All stroke | WHI | 1.8% | 1.3% | 31% (2 to 68) | 220 (120 to 1265) |
| Ischaemic stroke | WHI | 1.5% | 1.0% | 44% (9 to 90) | 213 (124 to 743) |
| Probable dementia | WHIMS | 1.8% | 0.9% | 105% (21 to 248) | 114 (63 to 461) |
| Difference between groups (CI) | |||||
| Mean 3MSE scores at baseline | WHIMS | 95.5 | 95.63 | −0.13 (−0.37 to 0.11) | |
| Mean rate of increase in 3MSE scores per year | WHIMS | 0.149 | 0.213 | −0.063 (−0.120 to −0.006)‡ | |