Immediate v delayed antibiotics in children with acute otitis media by day 3§

Outcomes in children with fever (temperature >37.5°C) or vomiting at diagnosisImmediate antibioticsDelayed antibioticsRRR (95% CI)NNT (CI)
Distress32%53%40% (16 to 57)5 (3 to 14)
Night disturbance26%59%56% (37 to 70)3 (2 to 5)
Outcomes in children without fever or vomiting
§Abbreviations defined in glossary; RRR, NNT, and CI calculated from data in article.
Distress15%19%21% (−45 to 57)Not significant
Night disturbance20%27%26% (−22 to 55)Not significant