Outcomes | 10 mg loading dose | 5 mg loading dose | Mean difference (95% CI) | |
---|---|---|---|---|
†INR = international normalised ratio. Other abbreviations defined in glossary; mean difference, RBI, RRR, RRI, NNT, NNH, and CI calculated from data in article. | ||||
Time to therapeutic INR >1.9 | 4.2 days | 5.6 days | 1.4 days (1.1 to 1.7) | |
RBI (CI) | NNT (CI) | |||
Patients with therapeutic INR at 5 days | 83% | 46% | 78% (43 to 128) | 3 (3 to 5) |
RRI (CI) | NNH | |||
Venous thromboembolism at 90 days | 2.9% | 0% | ∞ | Not significant |
RRR (CI) | NNT | |||
Major bleeding at 28 days | 0.96% | 1.0% | 6.7% (−786 to 90) | Not significant |
Death at 90 days | 0% | 1.0% | 100% (−256 to 100) | Not significant |