5 mg v 10 mg loading dose of warfarin for a warfarin nomogram in venous thromboembolism†

Outcomes10 mg loading dose5 mg loading doseMean difference (95% CI)
†INR = international normalised ratio. Other abbreviations defined in glossary; mean difference, RBI, RRR, RRI, NNT, NNH, and CI calculated from data in article.
Time to therapeutic INR >1.94.2 days5.6 days1.4 days (1.1 to 1.7)
RBI (CI) NNT (CI)
Patients with therapeutic INR at 5 days83%46%78% (43 to 128)3 (3 to 5)
RRI (CI) NNH
Venous thromboembolism at 90 days2.9%0%Not significant
RRR (CI) NNT
Major bleeding at 28 days0.96%1.0%6.7% (−786 to 90)Not significant
Death at 90 days0%1.0%100% (−256 to 100)Not significant