Outcomes (mean change from baseline to 12 mo) | Rofecoxib | Placebo | Mean difference (95% CI) |
---|---|---|---|
*Higher change scores indicate greater declines regardless of sign. | |||
†ADAS-cog = AD Assessment Scale – cognitive subscale. Total scores range from 0–70 errors. | |||
‡CIBIC+ = Clinician’s Interview Based Impression of Change with caregiver input, a 7 point scale ranging from 1 = very much improved to 7 = very much worse. Reported values are change from a default score of 4 at baseline (no change); increase of approximately 1 point corresponds to “minimal worsening.” | |||
ADAS−cog† | 4.84 | 5.44 | −0.60 (−1.90 to 0.70) |
CIBIC+‡ | 0.90 | 0.87 | 0.03 (−0.12 to 0.18) |