Rofecoxib v placebo in patients with Alzheimer’s disease*

Outcomes (mean change from baseline to 12 mo)RofecoxibPlaceboMean difference (95% CI)
*Higher change scores indicate greater declines regardless of sign.
†ADAS-cog  =  AD Assessment Scale – cognitive subscale. Total scores range from 0–70 errors.
‡CIBIC+  =  Clinician’s Interview Based Impression of Change with caregiver input, a 7 point scale ranging from 1  =  very much improved to 7  =  very much worse. Reported values are change from a default score of 4 at baseline (no change); increase of approximately 1 point corresponds to “minimal worsening.”
ADAS−cog†4.845.44−0.60 (−1.90 to 0.70)
CIBIC+‡0.900.870.03 (−0.12 to 0.18)