Non-steroidal anti-inflammatory drugs (NSAIDs) v paracetamol in osteoarthritis of the knee or hip at 4–6 weeks*

OutcomesNumber of RCTs (n)Components of the NSAIDs groupStandardised mean difference (95% CI)
*RCTs  =  randomised controlled trials; meta-analyses were done using a random effects model. CI defined in glossary.
†Significant differences favour NSAIDs.
Overall change in pain and disability2 (405)Naproxen and diclofenac0.22 (0.02 to 0.43)†
Pain on motion2 (362)Naproxen and ibuprofen (2400 mg/d)0.24 (0.00 to 0.48)†
Naproxen and ibuprofen (1200 mg/d)0.18 (−0.06 to 0.42)
Pain at rest or general pain3 (589)Naproxen, ibuprofen (2400 mg/d), and diclofenac0.33 (0.15 to 0.50)†
Naproxen, ibuprofen (1200 mg/d), and diclofenac0.33 (0.15 to 0.51)†
Functional disability3 (589)Naproxen, ibuprofen (2400 mg/d), and diclofenac0.19 (0.01 to 0.37)†
Naproxen, ibuprofen (1200 mg/d), and diclofenac0.18 (0.00 to 0.35)†