Table 2

Medications commonly associated with discontinuation syndromes which require slow weaning

MedicationType of discontinuation syndromeClinical manifestations
α-BlockersW, RAgitation, headache, hypertension and palpitations
ACE-inhibitorsDHeart failure and hypertension
Antianginal agentsDAngina
AnticonvulsantsW, DAnxiety, depression and seizures
AntidepressantsW, DAkathisia, anxiety, chills, coryza, gastrointestinal distress, headache, insomnia, irritability, malaise, myalgia and depression
Antiparkinsonian agentsW, D, RHypotension, psychosis, pulmonary embolism, rigidity and tremor
AntipsychoticWDyskinesias, insomnia, nausea and restlessness
AnticholinergicsWAnxiety, nausea, vomiting, headache and dizziness
BaclofenW, RAgitation, anxiety, confusion, depression, hallucinations, hypertonia, insomnia, mania, nightmares, paranoia and seizures
BenzodiazepinesWAgitation, anxiety, confusion, delirium, insomnia and seizures
β-BlockersW, DAngina, anxiety, hypertension, acute coronary syndrome and tachycardia
CorticosteroidW, R, DAnorexia, hypotension, nausea, weakness, hypothalamic–pituitary–adrenal axis suppression and inflammatory states
DigoxinDHeart failure and palpitations
DiureticDHeart failure and hypertension
Narcotic analgesiaWAbdominal cramping, anger, anxiety, chills, diaphoresis, diarrhoea, insomnia and restlessness
NSAIDsDRecurrence of gout and arthritis
  • D, disease recrudescence; NSAID, non-steroidal anti-inflammatory drug; R, rebound; W, withdrawal.