Numbers needed to treat and numbers needed to harm for key benefits and risks with buprenorphine implant
| Outcome name | Number needed to treat (NNT) | Number needed to harm (NNH) | 95% CI |
| Benefits | |||
| Improved compliance and convenience | 5.00 | Not calculable* | |
| Reduced risk of illicit opioid use | 11.38 | 5.99 to 113.64 | |
| Quality of life measures | 32.26 | Not calculable* | |
| Risk of misuse and diversion | Not calculable† | Not calculable† | Not calculable |
| Risks | |||
| Migration/missing implant | 100.00 | −250.00 to 41.67 | |
| Clinically significant implant breakage | 200.00 | 111.11 to 1000.00 | |
| Infection at insertion/removal site | 12.77 | 8.13 to 30.21 | |
| Implant-related allergic reaction | 14.62 | 8.93 to 40.00 |
*Data not available to calculate 95% CI.
†Spontaneous reporting data only; data not available to calculate NNT or NNH.