Table 1

Characteristics and details of the systematic review course for Brazilian regulatory agency of supplementary healthcare system

Item	Description
Title	Practical course of systematic review and meta-analysis
Objectives	To acquire knowledge about the methods of systematic reviews and develop ability for conducting a systematic review.
Support team	One coordinator and senior professor, three professors with advanced to intermediate skills on Cochrane and non-Cochrane systematic reviews and three tutors with intermediate experience on systematic reviews and remote learning methods. All the team received 4 hours training in active methodologies for distance learning.
Modality	Distance learning
Duration, total hours	Total course duration=96 hours Theoretical activities=35 hours Tutoring sections=24 hours Activities for developing a systematic review=33 hours Oral presentation of systematic review developed=4 hours
Duration, weeks	11
Learning management platform	CANVAS (https://www.instructure.com/canvas/pt-br) for uploading support materials and organisational aspects (work groups division, register of audience frequency) Zoom platform (https://zoom.us/) for classrooms and tutoring sessions WhatsApp for rapid communication among tutors and their work groups GoogleForms for pretest and post-test assessments and satisfaction questionary assessment
Audience	24 participants (divided into 3-person or 4-person work groups)
Content	Introduction of systematic review Defining the research question (PICO acronym) Eligibility criteria Searching for studies (search strategies, data sources) Selecting studies and extracting data (online platforms) Data synthesis (qualitative and meta-analysis) Additional analyses (subgroup, sensitivity) Risk of bias assessment (Cochrane tool) Rating the certainty of the evidence (GRADE approach, GRADEpro GDT) Oral presentation of the final systematic review
Teaching and learning methods	Hands-on course, using active methodologies. Two hours/week for theoretical classrooms (all audience) Two hours/week for tutoring section (one tutor for work group) Five hours for hands-one activities for developing a protocol and a systematic review A dedication of at least 8 hours per week is expected from each participant in order to achieve the course objectives
Sources and materials of support	Cochrane Handbook for Systematic Reviews of Interventions was recommended as main source of support.2
Learning evaluation	Participants were evaluated by The attendance in the theoretical activities and tutoring sections. The completion of the stage of a systematic review designated by the week. The quality of the systematic reviews assessed by tutors, professors and coordinators during the oral presentation at the last remote meeting. Pretest and post-test with 10 practical and conceptual multiple-choice questions about systematic reviews.
Titles of systematic reviews which has been conducted	The choice of titles was based on (1) clinical relevance; (2) relevance for the agency context; (3) absence of similar, well-done and update systematic reviews and (4) feasibility for being conducted over 11 weeks. Curcuma for patients with Alzheimer Electroconvulsive therapy for patients with drug-resistant major depression Electroconvulsive therapy for patients with severe major depression Erdafitinib for patients with urothelial carcinoma Neuroleptics for patients with bipolar affective disorder Pembrolizumab compared with axitinib for patients with renal cell carcinoma Prone position for patients with acute respiratory distress syndrome Thrombopoietin receptor agonists for patients with idiopathic thrombocytopaenic purpura
Criteria for certification/approval	To be approved, the participant should achieve 70% or more grade in the course evaluations and a minimum of 75% attendance in all activities.
Audience satisfaction	At the end of the course, the audience are invited to fulfil a GoogleForm with questions related to the quality and the overall grade of satisfaction with the course (considering the content, professor and tutor capability, learning methods, course duration, practical applicability and suggestions for improvement).