The effect of caffeine on placental and fetal blood flow in human pregnancy
References (16)
- et al.
Simultaneous single isotope radioentsymatic assay of plasma norepinephrine, epinephrine and dopamine
Life Sci
(1977) - et al.
Placental blood flow during caesarean section under lumbar extradural analgesia
Br. J. Anaesth
(1978) - et al.
Effect of the offspring of repeated caffeine administration to pregnant rats
J. Reprod. Fertil
(1976) - et al.
Adverse effects of prolonged administration of caffeine on rat fetus
Toxicol. Appl. Pharmacol
(1972) - et al.
Determination of caffeine in serum and urine
Clin. Chem
(1969) - et al.
Measurement of intervillous and myometrial blood flow by an intravenous 133Xe method
Br. J. Obstet. Gynaecol
(1976) - et al.
Measurement of human fetal blood flow
Br. Med. J
(1980) - et al.
Fetal and intervillous blood flow measurements in late pregnancy
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Caffeine intake during pregnancy and adverse outcomes: An integrative review
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2022, Reproductive and Developmental ToxicologyCaffeine: A potential strategy to improve survival of neonatal pigs and sheep
2021, Animal Reproduction ScienceCitation Excerpt :Many hepatic enzymes required to metabolise caffeine are absent in the fetus (Cazeneuve et al., 1994) and is inefficiently cleared through renal elimination (up to 90 %); clearance rates ten-fold less in human neonates compared with adults (Aldridge et al., 1979; Ginsberg et al., 2004). As clearance rates decrease as gestational period advances (Grosso et al., 2008), greater than optimal maternal caffeine concentrations can interfere with the catabolism of cAMP and lead to uterine vasoconstriction and decreased maternal-placental blood flow (Kirkinen et al., 1983; Grosso and Bracken, 2005). While a restriction in uterine blood flow can have marked effects on fetal development (Lang et al., 2003), caffeine accelerates lung development and function, and has now become well-established in paediatric medicine to treat premature infants (Aranda et al., 2010; Henderson-Smart and De Paoli, 2010; Abdel-Hady et al., 2015).
Associations between consumption of coffee and caffeinated soft drinks and late stillbirth—Findings from the Midland and North of England stillbirth case-control study
2021, European Journal of Obstetrics and Gynecology and Reproductive BiologyImpacts of Caffeine during Pregnancy
2020, Trends in Endocrinology and MetabolismCitation Excerpt :In addition, a single administration of caffeine on day 12 of pregnancy in rats significantly reduced blood flow to the maternal ovary, uterus, and decidua [43], which may lead to vasoconstriction in the uteroplacental circulation and compromise the ability of the placenta to transfer nutrients to the developing embryo. Moreover, increased serum adrenaline concentration and significantly decreased (∼25%) intervillous placental blood flow have been reported in pregnant women after ingesting two cups of coffee during the last trimester [44]. These findings suggest that middle and late gestational caffeine exposure can have a profound effect on both embryonic and placental development, and could explain the observed IUGR associated with gestational caffeine consumption in humans [5].