Original researchMeeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure
Section snippets
Materials and methods
We recruited patients with spontaneous premature ovarian failure under a protocol approved by the Institutional Review Board of the National Institute of Child Health and Human Development. Subjects gave informed consent. Patients qualified for referral if, before age 40 years, they had experienced at least 4 months of amenorrhea in association with two serum follicle-stimulating hormone levels greater than 40 mIU/mL (sampled at least 1 month apart). Patients with known abnormal karyotypes or
Results
All 50 women with spontaneous premature ovarian failure agreed to participate; two women, however, ultimately did not participate in the survey because of scheduling difficulties. The mean age of the 48 women who completed the structured interview was 33.5 ± 4.8 years. Ninety percent (43 of 48) of patients were college graduates, 40% (19 of 48) had graduate degrees, and all had completed high school. Three women were Hispanic, four were Asian, six were black, and 35 were white. In 24 of the
Discussion
More aggressive evaluation and intervention for young women with amenorrhea and estrogen deficiency has been advocated.5, 6 Estrogen deficiency is a well-established risk factor for osteoporosis. Gonadal steroids play an important role in maintaining skeletal health throughout life in both men and women.7 Evidence suggests that more attention should be paid to the skeletal health of young women with amenorrhea. Bone mineral loss is known to occur in these young women, and the amount of loss is
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Optimising health after early menopause
2024, The LancetHormone therapy in women with premature ovarian insufficiency: a systematic review and meta-analysis
2022, Reproductive BioMedicine OnlineSurvey of Canadian PGY-4 and PGY-5 Obstetrics and Gynaecology Residents on Knowledge of and Exposure to Premature Ovarian Insufficiency
2018, Journal of Obstetrics and Gynaecology CanadaCitation Excerpt :Creating clinical practice guidelines for POI in Canada is one way to streamline an approach to POI patients among trainees and practitioners. This may increase awareness among physicians about appropriate work-up for amenorrhea in young women and diagnosis of this condition, potentially avoiding treatment delay as shown by Alzubaidi et al.6 In the American obstetrics and gynaecology resident group, there is a lack of exposure to menopause.8