Cardiology/original researchMulticenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T
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Please see page 77 for the Editor’s Capsule Summary of this article.
Supervising editor: Judd E. Hollander, MD
Author contributions: CM, SW, and BL designed the study. CM and BL reviewed the literature. CM wrote the article. CM, EG, MC, JO-L, CdF, JM, RB, M. Panteghini, TJ, M. Plebani, FV, and JF recruited patients and interpreted results. EG, MC, JO-L, CdF, JM, RB, M. Panteghini, TJ, M. Plebani, FV, JF, RC, SW, GB, PD, and BL critically reviewed the article. CM, EG, MC, JO-L, CdF, JM, RB, M. Panteghini, TJ, M. Plebani, FV, JF, and RC collected data. RC measured samples. SW and GB managed the study. CM, GB, PD, and BL analyzed and interpreted the study data. PD was the study statistician. All authors have read and approved the final article and take final responsibility for the decision to submit for publication in the present form. CM takes responsibility for the paper as a whole.
Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The study was sponsored by Roche Diagnostics. Dr. Mueller has received research support from the European Union, the Swiss National Science Foundation, the Swiss Heart Foundation, the Cardiovascular Research Foundation Basel, Abbott, Alere, AstraZeneca, Beckman Coulter, BRAHMS, Critical Diagnostics, Roche, Siemens, Singulex, Sphingotec, and the Department of Internal Medicine, University Hospital Basel, as well as speaker and consulting honoraria or travel support from Abbott, Alere, AstraZeneca, Bayer, BG Medicine, bioMérieux, BRAHMS, Cardiorentis, Daiichi Sankyo, Eli Lilly, MSD, Novartis, Radiometer, Roche, Siemens, and Singulex. Dr. Giannitsis has received honoraria for lectures from Roche Diagnostics, BRAHMS ThermoFisher, and Mitsubishi Chemical Europe; has received an institutional research grant from Roche Diagnostics; and serves as a consultant for Roche Diagnostics and BRAHMS ThermoFisher. Dr. Christ has received research support and speaking honoraria from Roche, ThermoFisher, and Novartis. Dr. Ordóñez-Llanos reports grants, personal fees, and nonfinancial support from Roche Diagnostics during the conduct of the study; grants, personal fees, and nonfinancial support from Abbott Diagnostics; personal fees and nonfinancial support from Alere Diagnostics; nonfinancial support from Critical Diagnostics; and other support from Stat Diagnostics and ThermoFisher outside the submitted work. Dr. deFilippi reports grants and personal fees from Roche Diagnostics during the conduct of the study, grants and personal fees from Critical Diagnostics, grants from BG Medicine, nonfinancial support from Alere, personal fees from Radiometer, personal fees from Siemens Healthcare, personal fees from Singulex, and personal fees from HDL outside the submitted work. In addition, Dr. deFilippi has patent 61/990,386 pending. Dr. McCord has received research support from Roche. Dr. Body has accepted travel and accommodation for conferences from Roche Diagnostics and Randox Laboratories, and has undertaken research supported by the donation of reagents by Roche Diagnostics, Siemens Healthcare Diagnostics, Randox Laboratories, Alere, and Abbott Laboratories. Dr. Panteghini received a research grant from Roche Diagnostics during the course of the study. Dr. Plebani reports an institutional research grant from Roche. Dr. French reports grants from The Medicines Company and other support from The Medicines Company, Boehringer Ingelheim, Eli Lilly, sanofi-aventis, Bayer, and AstraZeneca outside the submitted work. Dr. Christenson reports personal fees from Roche Diagnostics outside the submitted work. Drs. Weiser, Bendig, and Dilba are employees of Roche Diagnostics. Dr. Lindahl has served as a consultant for Roche Diagnostics, Beckman Coulter Inc., Siemens Healthcare Diagnostics, Radiometer Medical, bioMérieux Clinical Diagnostics, Philips Healthcare, and Fiomidiagnostics AB; has received a lecture fee from ThermoFisher; and has received research grants from Roche Diagnostics, Fiomidiagnostics AB, and bioMérieux Clinical Diagnostics. All other authors declare that they have no conflict of interest with this study. Alisa Davis and Steve Winter were supported by Roche Diagnostics.
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A list of additional contributors in the TRAPID-AMI study is provided in Table E1, available online at http://www.annemergmed.com.