Objective: To examine the effects of low to moderate maternal alcohol consumption and binge drinking in early pregnancy on behaviour in children at the age of 5 years.
Design: Prospective cohort study.
Setting: Neuropsychological testing in four Danish cities, 2003-2008.
Population: A total of 1628 women and their children sampled from the Danish National Birth Cohort.
Methods: Participants were sampled based on maternal alcohol drinking patterns during early pregnancy. When the children were 5 years of age the parent and teacher versions of the Strengths and Difficulties Questionnaire (SDQ) were completed by the mothers and a preschool teacher, respectively. The full statistical model included the following potential confounding factors: maternal binge drinking or low to moderate alcohol consumption, respectively; parental education; maternal IQ; prenatal maternal smoking; the child's age at testing; the child's gender; maternal age; parity; maternal marital status; family home environment; postnatal parental smoking; prepregnancy maternal body mass index (BMI); and the child's health status.
Main outcome measure: Behaviour among children assessed by the SDQ parent and teacher forms.
Results: Adjusted for all potential confounding factors, no statistically significant associations were observed between maternal low to moderate average weekly alcohol consumption and SDQ behavioural scores (OR 1.1, 95% CI 0.5-2.3; OR 1.1, 95% CI 0.6-2.1 for the total difficulties scores) or between binge drinking and SDQ behavioural scores (OR 1.2, 95% CI 0.8-1.7; OR 0.8, 95% CI 0.6-1.2).
Conclusion: This study observed no consistent effects of low to moderate alcohol consumption or binge drinking in early pregnancy on offspring behaviour at the age of 5 years.
Keywords: Behaviour; SDQ; Strengths and Difficulties Questionnaire; binge drinking; low to moderate alcohol consumption; neurodevelopmental effects; prenatal exposures.
© 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.