1 From the Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard University (B.E.B., R.L., M.B.), Boston and Cambridge; the Department of Medicine, Brigham and Women's Hospital (B.E.B., R.L.), the Department of Medicine (B.E.B., R.L.), and the Center for Bioethics (B.E.B., R.L., M.B.), Harvard Medical School, and Ropes and Gray (M.B.) - all in Boston; Yale Law School, New Haven (M.B.); and the University of California, San Francisco, San Francisco (I.S.).